Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during

autophagy pathway p62  Simultaneously they were encircled by an adaptor protein p62SQSTM1 and directed to the autophagy-lysosome pathway in HEK293 cell line Most phospho-α Attenuation of cGAS-STING signaling is mediated by a p62SQSTM1-dependent autophagy pathway activated by TBK1 -article

autophagy pathway There are other drugs in development that build This P62 Antibody Is a Good Marker for Autophagy Induction A In the absence of p62, STING failed to traffic to autophagy‐associated vesicles Thus, DNA sensing induces the cGAS‐STING pathway to activate TBK1, which

The UPS and autophagy are two major intracellular degradation routes and p62 is a key mediator of crosstalk between these pathways  p62 is essential for mTORC1 activation in response to arginine, but it is not a direct sensor of free arginine in the mTORC1 pathway We