ALS-FTLD-linked mutations of SQSTM1p62 disrupt selective

autophagy pathway p62 p62LC3 autophagic pathway Conclusions These Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

The review summarizes the molecular mechanisms of interaction of the autophagy protein p62 with cell defense systems, primarily through the NRF2KEAP1ARE p62vom Interestingly, our laboratory's long-time interest SQSTM1p62 has also been shown to be critical for aggregation of misfolded proteins and their autophagic